METHODS OF MEASURING THE DISSOLUTION RATE OF AN ANALYTE IN A NON-AQUEOUS LIQUID COMPOSITION
摘要
A method is provided for determining the dissolution rate of an analyte, which is preferably a pharmaceutically active component in a sustained release dosage form. The method comprises(i) contacting a diluted non-aqueous composition containing the analyte and a non-aqueous base, such as a wax or a fat, with an aqueous dissolution medium for a predetermined time, and (ii) measuring the amount of anaalyte in the aqueous dissolution medium.
申请公布号
WO2004051263(A1)
申请公布日期
2004.06.17
申请号
WO2003US25854
申请日期
2003.09.10
申请人
PHARMACIA & UPJOHN COMPANY;SCHAPAUGH, RANDAL, LEE;CIOLKOWSKI, EDWARD, L.;EATON, LESLIE, C.
发明人
SCHAPAUGH, RANDAL, LEE;CIOLKOWSKI, EDWARD, L.;EATON, LESLIE, C.