METHOD FOR PRODUCING SALTS OF TOLPERISONE

摘要

The invention relates to a method for producing an addition salt of 2,4'- dimethyl-3-piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of formula (I). According to the invention, 4- methylpropiophenone is reacted with piperidine hydrochloride and 1,2-dioxola ne in the presence of an acid serving as a catalyst, and the tolperisone obtain ed in the form of an acid addition salt is separated by filtering after the reaction mixture has cooled down.