发明名称 |
Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
摘要 |
A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.
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申请公布号 |
US2004116724(A1) |
申请公布日期 |
2004.06.17 |
申请号 |
US20030609124 |
申请日期 |
2003.06.30 |
申请人 |
KINNEY WILLIAM A.;JONES STEVEN;ZHANG XUEHAI;RAO MEENA N.;BULLIARD MICHEL;MECKLER HAROLD;LEE NANCY |
发明人 |
KINNEY WILLIAM A.;JONES STEVEN;ZHANG XUEHAI;RAO MEENA N.;BULLIARD MICHEL;MECKLER HAROLD;LEE NANCY |
分类号 |
C07J9/00;C07J31/00;C07J41/00;(IPC1-7):C07J1/00;C07C29/14 |
主分类号 |
C07J9/00 |
代理机构 |
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