Heterogeneous foldamers containing alpha, beta, and/or gamma-amino acids

摘要

Disclosed are isolated, unnatural polypeptides containing cyclically-constrained beta-amino acid residues and cyclically-constrained gamma-amino acid residues. The compounds are unnatural and because they contain rotationally constrained residues that are not amenable to enzymatic degradation, the compounds are useful to probe protein-protein and other large molecule interactions.