摘要 |
This invention describes novel pyrazole compounds of formula II: wherein Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, and R<2>, R<2'>, R<x>, and R<y >are as described in the specification. Ring C has an ortho substituent and is optionally substituted in the non-ortho positions. R<2 >and R<2'> are optionally taken together with their intervening atoms to form a fused ring system, such as an indazole ring; and R<x >and R<y >are optionally taken together with their intervening atoms to form a fused ring system, such as a quinazoline ring. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3, for treating diseases such as diabetes and Alzheimer's disease.
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