| 发明名称 |
BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT HYPERLIPIDAEMIA |
| 摘要 |
The present invention relates to compounds of formula (I) wherein R<SUP>v</SUP>, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>x</SUP>, R<SUP>y</SUP>, M, R<SUP>z</SUP>, v, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5 </SUP>and R<SUP>6 </SUP>are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described. |
| 申请公布号 |
EP1427423(A1) |
申请公布日期 |
2004.06.16 |
| 申请号 |
EP20020765013 |
申请日期 |
2002.09.05 |
| 申请人 |
ASTRAZENECA AB |
发明人 |
STARKE, INGEMAR;DAHLSTROM, MIKAEL, ULF, JOHAN;BLOMBERG, DAVID;ALENFALK, SUZANNE;SKJARET, TORE;LEMURELL, MALIN |
| 分类号 |
A61K;A61K31/192;A61K31/397;A61K31/40;A61K31/505;A61K31/554;A61K31/695;A61K31/785;A61P;A61P3/06;A61P7/02;A61P9/00;A61P9/04;A61P9/06;A61P9/08;A61P9/10;A61P17/02;A61P31/00;A61P43/00;C07D;C07D281/02;C07D281/10;C07D285/36;C07D417/12;C07F7/10;C07K;(IPC1-7):A61K31/554;C07K5/065;C07K5/087;A61K38/05;A61K38/06 |
主分类号 |
A61K |
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