发明名称 |
Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
摘要 |
A method for killing malignant brain tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with defective expression of the gamma 34.5 gene and the ribonucleotide reductase gene, specifically destroys tumor cells, is hypersensitive to anti-viral agents, and yet is not neurovirulent.
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申请公布号 |
EP1428887(A1) |
申请公布日期 |
2004.06.16 |
申请号 |
EP20040001555 |
申请日期 |
1995.06.23 |
申请人 |
GEORGETOWN UNIVERSITY |
发明人 |
MARTUZA, ROBERT L.;RABKIN, SAMUEL D.;MINETA, TOSHIHIRO |
分类号 |
C12N15/09;A01K67/027;A61K38/00;A61K39/00;A61K39/12;A61K48/00;A61P35/00;C07H21/04;C07K14/035;C12N7/00;C12N7/01;C12N15/85;C12N15/869;C12R1/92;(IPC1-7):C12N15/869;A61K35/76;A61K39/245 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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