发明名称 |
NOVEL AMORPHOUS HYDRATE OF A CEPHALOSPORIN ANTIBIOTIC |
摘要 |
<p>A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a tertiary amine and an organic solvent, followed by treatment with a base to produce a salt of compound formula (XIV), wherein M+ is a counter ion and ii) hydrolyzing the compound of the formula (XIV) using an acid in the presence of a solvent to produce cefdinir of formula (I).</p> |
申请公布号 |
AU2003276525(A1) |
申请公布日期 |
2004.06.15 |
申请号 |
AU20030276525 |
申请日期 |
2003.11.10 |
申请人 |
ORCHID CHEMICALS AND PHARMACEUTICALS LTD |
发明人 |
CHANDRASEKARAN RAMASUBBU;PANDURANG, BALWANT DESHPANDE;BHAUSAHEB, PANDHARINATH KHADANGALE |
分类号 |
C07D501/00;C07D501/06;C07D501/22;(IPC1-7):C07D501/06 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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