PHOSPHOLIPID- OR LIPID-LINKED GLYCOSAMINOGLYCAN, PROCESS FORPRODUCING THE SAME AND METASTASIS INHIBITOR

摘要

This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their excellent function to inhibit adhesion of cancer cells to blood vessel endothelial cells and extracellular matrix. This phospholipid- or lipid-linked glycosaminoglycan can be produced for example by: cleaving and oxidizing reducing terminal group of glycosaminoglycan, and allow- ing an aldehyde group or a lactone compound of the thus- formed derivative or a carboxyl group in the glycos- aminoglycan chain to react with a primary amino group of a phospholipid; or linking a glycosaminoglycan deriva- tive to a phospholipid or a lipid by allowing a primary amino group of the derivative to react with a carboxyl group of the phospholipid or lipid. This phospholipid- or lipid-linked glycosaminoglycan is useful as a metastasis inhibitor because it has no toxicity.