发明名称 |
ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND MATERIALS FOR THEIR SYNTHESIS |
摘要 |
Compounds of the formula:where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula:where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described. |
申请公布号 |
PL356062(A1) |
申请公布日期 |
2004.06.14 |
申请号 |
PL20000356062 |
申请日期 |
2000.12.01 |
申请人 |
AGOURON PHARMACEUTICALS,INC. |
发明人 |
DRAGOVICH PETER S.;PRINTS THOMAS J.;ZHOU RU;JOHNSON THEODORE O.JR. |
分类号 |
A61K31/437;A61K31/44;A61K31/4412;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61P31/12;A61P31/14;A61P31/16;A61P43/00;C07D;C07D213/75;C07D401/12;C07D405/12;C07D405/14;C07D409/12;C07D413/12;C07D413/14;C07D471/04 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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