发明名称 |
N-FORMYL PEPTIDE RECEPTOR COMPLEX WITH A G-PROTEIN KINASE SIGNAL PATHWAY MODIFICATION AGENT |
摘要 |
A method of inhibiting a pro-inflammatory response of a human peripheral blood mononuclear cell or polymorphonuclear cell, or fixed tissue cell is described. The cell is contacted with a pro-inflammatory agent to stimulate a pro-inflammatory response. Then, the cell is contacted with a G protein kinase signal pathway modification agent, thereby inhibiting inflammatory response signal transduction pathways mediated by G protein. A receptor complex is described wherein a G protein kinase signal pathway modification agent binds to a cell surface receptor of a human peripheral blood mononuclear cell or polymorphonuclear cell that has been stimulated by a pro-inflammatory agent. |
申请公布号 |
PL356096(A1) |
申请公布日期 |
2004.06.14 |
申请号 |
PL20000356096 |
申请日期 |
2000.10.12 |
申请人 |
HISTATEK,LLC |
发明人 |
CLAGETT JAMES A.;PALMER CRAIG |
分类号 |
G01N33/50;A61K38/00;A61K38/05;A61K38/07;C07K5/083;C07K5/103;C07K14/705;C07K14/72;C12N5/06;C12Q1/02;G01N33/15 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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