发明名称 |
Antiiinflammatory Centella asiatica extracts useful in medicinal or cosmetic compositions, contain madecassoside and terminoloside, obtained by processing alcoholic extract |
摘要 |
Production of an extract (A) of Centella asiatica, containing a mixture of madecassoside (I) and terminoloside (II), involves: (a) extracting above-ground plant parts with alcoholic solvent; (b) passing the extract through anionic resin; (c) selectively defatting the eluate; (d) concentrating the aqueous alcoholic phase to an aqueous phase, then filtering; (e) passing the aqueous phase through cationic resin then anionic resin; (f) stabilizing and (g) chromatographing. Production of an extract (A) of Centella asiatica, containing a mixture of madecassoside (I) and terminoloside (II), involves: (a) extracting above-ground plant parts with alcoholic solvent; (b) passing the extract through anionic resin; (c) selectively defatting the eluate by liquid-liquid extraction; (d) concentrating the aqueous alcoholic phase to an aqueous phase, then filtering; (e) passing the aqueous phase through cationic resin then anionic resin; (f) stabilizing by addition of alcohol; (g) selectively chromatographing, and (h) recovering the (I)/(II) mixture. An Independent claim is included for the extracts (A) obtained by the process, containing more than 95 wt. % of the (I)/(II) mixture and preferably having an overall (I) content of 30-70%.
|
申请公布号 |
FR2848117(A1) |
申请公布日期 |
2004.06.11 |
申请号 |
FR20020015613 |
申请日期 |
2002.12.10 |
申请人 |
ROCHE CONSUMER HEALTH LTD |
发明人 |
LOISEAU ALAIN;SENE GERARD;THERON ERIC |
分类号 |
A61K8/97;A61K36/23;A61P17/00;A61P19/00;A61P29/00;A61Q19/00;A61Q19/08;(IPC1-7):A61K35/78;A61K7/40 |
主分类号 |
A61K8/97 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|