发明名称 |
Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
摘要 |
The invention provides compounds of formula I: wherein: R1-R5, "a" and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.
|
申请公布号 |
US2004110782(A1) |
申请公布日期 |
2004.06.10 |
申请号 |
US20030638943 |
申请日期 |
2003.08.11 |
申请人 |
LAVOIE EDMOND J.;SINGH SUDHIR K.;LIU LEROY F. |
发明人 |
LAVOIE EDMOND J.;SINGH SUDHIR K.;LIU LEROY F. |
分类号 |
A61P35/00;C07D221/18;C07D471/04;(IPC1-7):A61K31/473;A61K31/474;C07D491/02;C07D221/22 |
主分类号 |
A61P35/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|