The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method.
申请公布号
WO03080855(A3)
申请公布日期
2004.06.10
申请号
WO2003GB01198
申请日期
2003.03.19
申请人
GLAXO GROUP LIMITED;ALEXEEVA, MARINA, VICTOROVNA;ENRIGHT, ALEXIS;TURNER, NICHOLAS, JOHN;MAHMOUDIAN, MAHMOUD