发明名称 |
DERMAL DELIVERY OF A WATER-SOLUBLE SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, E.G. PARECOXIB AND VALDECOXIB |
摘要 |
A pharmaceutical composition for application to an area of skin of a subject for local and/or systemic treatment of a COX-2 mediated disorder comprises a backing sheet that is flexibly conformable to the area of skin, the backing sheet having opposing surfaces that are respectively distal and proximal to the skin when applied; and a coating on the proximal surface of the backing sheet that comprises (a) an adhesive and (b) an active agent comprising valdecoxib or a prodrug thereof or a salt thereof, the active agent being in a therapeutically effective total amount and dispersed in a matrix that comprises zero to less than an active agent solubilizing effective amount in total of one or more solvents other than the adhesive. A method of local treatment of a site of pain and/or inflammation in a subject comprises applying the composition to a skin surface of the subject, preferably at a locus overlying or adjacent to the site of pain and/or inflammation, and leaving the composition in place for a time period effective to permit delivery of a locally therapeutic amount of the active agent. A method of systemic treatment of a subject having a COX-2 mediated disorder comprises applying the composition to a skin surface of the subject, and leaving the composition in place for a time period effective to permit transdermal delivery of a therapeutic amount of the active agent.
|
申请公布号 |
CA2501287(A1) |
申请公布日期 |
2004.06.10 |
申请号 |
CA20032501287 |
申请日期 |
2003.11.12 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
STOLLER, BRENDA M.;LU, GUANG WEI;EWING, GARY D.;KIENLE, KATHRYN M. |
分类号 |
A61K9/70;A61K31/35;A61K31/415;A61K31/42;(IPC1-7):A61K9/70 |
主分类号 |
A61K9/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|