摘要 |
The invention relates to therapeutic modalities and pharmaceutical compositions for the treatment of Chlamydia-infection using cyclophilin polypeptides and its corresponding human cellular binding partner or partners as a target for intervention. The present invention relates to the use of exogenous or engrafted sources of cyclophilins, anti-cyclophilin antibodies, cyclophilin decoys, soluble forms of cyclophilin-binding partners and small molecules which are supplied extracellularly, and act presumably by interrupting the binding of cyclophilin A with its cellular binding partner(s) or receptor(s), as a treatment for Chlamydia-infection. The present invention further relates to screening assays for the identification of compounds that inhibit the interaction of cyclophilin and its Chlamydia binding partners. |
申请人 |
WYETH;WOOTERS, JOSEPH, L.;METCALF, BENJAMIN, J.;SANKARAN, BANUMATHI |
发明人 |
WOOTERS, JOSEPH, L.;METCALF, BENJAMIN, J.;SANKARAN, BANUMATHI |