| 摘要 |
The present invention relates to a compound represented by the following formula (I): (wherein, W represents W<A>-A<1>-W<B>- (in which, W<A >is substituted or unsubstituted aryl, etc., A<1 >is -NR<1>-, single bond, -C(O)-, etc., and W<B >is substituted or unsubstituted arylene, etc.), R is single bond, -NH-, -OCH2-, alkenylene, etc., X is -C(O)-, -CH2-, etc., and M is, for example, the following formula: (in which, R<11>, R<12 >and R<13 >each independently represents hydrogen, hydroxyl, amino, halogen, etc., R<14 >is hydrogen or lower alkyl, Y represents -CH2-O-, etc., Z is substituted or unsubstituted arylene, etc., A<2 >is single bond, etc, and R<10 >is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VAL-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.
|
