摘要 |
This invention is directed generally to heteroarylsulfonylmethyl hydroxamic acids and amides that, inter alia, tend to inhibit protease activity, particularly matrix metalloproteinase (also known as "matrix metalloprotease " or "MMP") activity and/or aggrecanase activity. This invention also is directed to compositions of such compounds; intermediates for the syntheses of such compounds; methods for making such compounds; and methods for treating conditions associated with MMP, tumor necrosis factors (or "TNFs"), and/or aggrecanase activity, particularly pathological conditions.
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申请人 |
PHARMACIA CORPORATION |
发明人 |
SPANGLER, DALE P.;SCHMIDT, MICHELLE A.;MASSA, MARK A.;KASSAB, DARREN J.;CARROLL, JEFFERY N.;HEINTZ, ROBERT M.;BECKER, DANIEL P.;RICO, JOSEPH G.;GRAPPERHAUS, MARGARET L.;PITZELE, BARNETT S.;FOBIAN, YVETTE M.;MCDONALD, JOSEPH J.;HANSEN, DONALD W., JR.;NAGY, MARK A. |