| 发明名称 |
RXR HOMODIMER FORMATION, BRIDGED BICYCLIC AROMATIC COMPOUND AND USE THEREOF IN CONTROLLED GENE EXPRESSION |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method of screening a substance for an ability to effect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing the retinoid X receptor and determining the presence of homodimer formation. <P>SOLUTION: The method of screening a substance for an ability to affect the formation of the retinoid X receptor homodimer, comprises processes for combining the substance and the solution containing the retinoid X receptor, determining the presence of homodimer formation and determining the presence of the homodimer by detecting activation of transcription through the retinoid X receptor homodimer. <P>COPYRIGHT: (C)2004,JPO |
| 申请公布号 |
JP2004159664(A) |
申请公布日期 |
2004.06.10 |
| 申请号 |
JP20040002452 |
申请日期 |
2004.01.07 |
| 申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION;SRI INTERNATL |
发明人 |
PHAHL MAGNUS;ZHANG XIAO-KUN;LEHMANN JURGEN M;DAWSON MARCIA I;CAMERON JAMES F;HOBBS PETER D;JONG LING |
| 分类号 |
G01N33/50;A61K31/19;A61K31/335;A61K31/357;A61K31/36;A61K31/38;A61K31/381;A61K31/385;A61K31/39;A61P3/00;A61P3/02;A61P5/12;A61P17/00;A61P31/12;A61P35/00;A61P35/02;A61P37/00;A61P43/00;C07C63/49;C07C63/66;C07C65/36;C07C69/738;C07C69/76;C07C233/64;C07D311/58;C07D317/30;C07D319/06;C07D327/04;C07D333/22;C07D333/38;C07D339/06;C07D339/08;C07D409/04;C07K14/705;C12N15/09;G01N33/15;G01N33/53;G01N33/566;G01N33/68;G01N33/74 |
主分类号 |
G01N33/50 |
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