发明名称 |
Restoring cancer-suppressing functions to neoplastic cells through DNA hypomethylation |
摘要 |
Compositions and methods are provided for treating diseases associated with abnormal cell proliferation such as cancer by restoring inherent tumor-suppressing functions of neoplastic cells through DNA hypomethylation. The method comprises: delivering to a patient suffering from cancer a therapeutically effective amount of a DNA methylation inhibitor such as decitabine, in combination with an effective amount of an anti-neoplastic agent whose activity as an anti-neoplastic agent in vivo is adversely affected by aberrant DNA methylation. The anti-neoplastic agent is preferably a biologic agent such as an interleukin.
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申请公布号 |
US2004109846(A1) |
申请公布日期 |
2004.06.10 |
申请号 |
US20030686047 |
申请日期 |
2003.10.14 |
申请人 |
SUPERGEN, INC. |
发明人 |
RUBINFELD JOSEPH;CHANG LUCY;DIMARTINO JORGE |
分类号 |
A61K45/06;A61K31/00;A61K31/07;A61K31/138;A61K31/203;A61K31/282;A61K31/495;A61K31/57;A61K31/706;A61K33/24;A61K39/395;A61P35/00;A61P43/00;(IPC1-7):A61K38/20;A61K31/707 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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