METHODS FOR COHORT SELECTION AND LONGEVITY STUDIES

摘要

This application includes methods and compositions for evaluating a genetic locus associated with longevity and methods for evaluating information from groups of individuals. A longevity-associated locus was identified in gene that encodes for the microsomal triglyceride transfer (MTP) protein on chromosome IV. The polymorphic markers in the region and their methods of us e are described. Also disclosed is a method for evaluating information which information for each individual of a first group of individuals and each individual of a second group of individuals is used to select a subset of individuals from the second group. The information can be about a plurality of different biological features. The selection can use a comparison between information for members of the first group and information for members of th e subset. It is also possible to compare members of the first group to members of the selected subset with respect to at least one factor. The method can b e used to reduce stratification, for example, in the analysis of genetic associations.