IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND USE

摘要

An imidazole derivative represented by the formula (I): (I) wherein R represents an optionally substituted cyclic hydrocarbon group or optionally substituted heterocyclic group; W represents a bond or optionally substitute d divalent chain hydrocarbon group; X represents an optionally substituted divalent hydrocarbon group; Y represents -CO-, -S(O)-, -S(O)2-, or a bond; ring A represents an optionally substituted pyrrolidine ring, optionally substituted piperidine ring, or optionally substituted perhydroazepine ring; Z1 and Z3 each independently represents a bond or optionally substituted divalent chain hydrocarbon group; Z2 represents -N(R1)-, -O-, -S(O)-, -S(O)2 -, -CO-, -CH(R1)-, or a bond; ring B represents an optionally substituted imidazole ring, provided that a substituent of the imidazole ring represente d by B may be bonded to R1 to form an optionally substituted ring; and a is 0, 1, or 2. The imidazole derivative is useful as a therapeutic agent for thrombosis.