| 摘要 |
Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I) wherein R<1 >through R<11 >are defined herein. Preferred R<4 >moieties are selected from O, S, NH and CH2, and in exemplary compounds, R<4 >is O and R<5 >is a tri-substituted aroyloxy substituent, such as a 3,4,5-substituted benzoyloxy group. Pharmaceutical compositions are provided as well, as are methods of chemotherapy and chemoprevention.
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