IRREGULARLY-SHAPED MACROPOROUS COPOLYMER PARTICLES AND METHODS OF USING SAME

摘要

A matrix comprising irregularly-shaped macroporous copolymer particles is disclosed. The matrix can be employed in various liquid chromatography applications, such as detecting the presence or absence of a heteroduplex structure in a mixture of hetero- and homoduplex structures. The non-monolithic crushed macroporous copolymer network can be packed in a chromatography column, and such columns facilitate high resolution separations, while maintaining low back pressures, short separation times and long column lifetimes. The irregularly-shaped macroporous copolymer particles can also be employed in analyte isolation operations.