发明名称 |
NUCLEIC ACID MEDIATED INHIBITION OF ENTEROCOCCUS INFECTION AND CYTOLYSIN TOXIN ACTIVITY |
摘要 |
The present invention relates to nucleic acid aptamers that bind to bacterial proteases such as CylA and methods for their use alone or in combination with other therapies, such as antibiotics. Also disclosed are nucleic acids such as siRNA, antisense, and enzymatic nucleic acid molecules that can modulate the expression of CylA genes. The compounds and methods of the invention are expected to inhibit enterococcus infection and cytolysin activity.
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申请公布号 |
WO03106476(A8) |
申请公布日期 |
2004.06.10 |
申请号 |
WO2003US18911 |
申请日期 |
2003.06.16 |
申请人 |
SIRNA THERAPEUTICS, INC;MORRISSEY, DAVID;HAEBERLI, PETER |
发明人 |
MORRISSEY, DAVID;HAEBERLI, PETER |
分类号 |
A61K38/00;A61K48/00;C07H21/04;C12N9/99;C12N15/113;C12N15/115;C12Q1/68;(IPC1-7):C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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