Process for preparing single enantiomers of 5,5,5,5',5',5'-hexafluoroleucine and protected analogs

摘要

A process for synthesizing L and D-5,5,5,5',5',5'-hexafluoroleucine and protected analogs is disclosed. These compounds have utility in the preparation of fluorous peptides and proteins, which display interesting and unusual properties including strong self-association and an affinity for lipid bilayers.