发明名称 |
STEREOSELECTIVE PROCESS FOR THE PRODUCTION OF DIOXOLANE NUCLEOSIDE ANALOGUES |
摘要 |
<p>The present invention relates to a process for producing a compound of formula (I); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Pig Liver Esterase or Porcine Pancreatic Lipase b) recovering said compound of formula (I). The invention also provides a process for producing a compound of formula (III); said process comprising the steps of: a) subjecting a compounds of formula (IV) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Candida Antarctica "A" lipase, Candida Antarctica "B" lipase, Candida Lypolitica Lipase or Rhizomucor Miehei Lipase b) recovering said compound of formula (III).</p> |
申请公布号 |
WO2004048590(A1) |
申请公布日期 |
2004.06.10 |
申请号 |
WO2003CA01798 |
申请日期 |
2003.11.18 |
申请人 |
SHIRE BIOCHEM INC.;CIMPOIA, ALEX;LALONDE, JAMES, JOSEPH |
发明人 |
CIMPOIA, ALEX;LALONDE, JAMES, JOSEPH |
分类号 |
C07D317/32;C12P17/04;C12P41/00;(IPC1-7):C12P41/00 |
主分类号 |
C07D317/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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