COMPOSITIONS AND METHODS FOR CELL DEDIFFERENTIATION AND TISSUE REGENERATION

摘要

The present invention provides methods and compositions to dedifferentiate a cell. The ability of the methods and compositions off the present invention to promote the dedifferentiation of differentiated cells, including terminally differentiated cells, can be used to promote regeneration of tissues and organs in vivo. The ability of the methods and compositions of the present invention to promote the dedifferentiation of differentiated cells, includin g terminally differentiated cells, can further be used to produce populations of stem or progenitor cells which can be used to promote regeneration of tissue s and/or organs damaged by injury or disease. Accordingly, the present inventi on provides novel methods for the treatment of a wide range of injuries and diseases that affect many diverse cell types.