| 摘要 |
<p>An improved process for the preparation of cefpodoxime proxetil of the formula (I) the said process comprises reacting cefpodoxime acid with 1-haloethyl isopropyl carbonate of the formula (VI) where X represents halogen atom such as chlorine, bromine or iodine using a base such as tetramethylguanidine, di-isopropylethyl amine, 1,5-diazabicyclo(4.3.0)non-5-ene (DBN), 1,4-diazabicyclo[2.2.2]octane (DABCO) in the presence of a solvent at a temperature in the range of -30 DEG C to 30 DEG C to produce cefpodoxime proxetil of the formula (I) and isolating the pure cefpodoxime proxetil of the formula (I).</p> |
| 申请人 |
ORCHID CHEMICALS & PHARMACEUTICALS LTD;DESHPANDE, PANDURANG, BALWANT;DAS, GAUTAM, KUMAR;LUTHRA, PARVEN, KUMAR;DESHPANDE, PRAMOD, NARAYAN;SUBRAMANIAN, SELVRAJ;KAMMA, RAMAKRISHNA |
发明人 |
DESHPANDE, PANDURANG, BALWANT;DAS, GAUTAM, KUMAR;LUTHRA, PARVEN, KUMAR;DESHPANDE, PRAMOD, NARAYAN;SUBRAMANIAN, SELVRAJ;KAMMA, RAMAKRISHNA |
