| 摘要 |
The present invention provides an alpha2c-adrenoceptor antagonist comprising, as an active ingredient, a condensed-ring-pyrimidine derivative represented by general formula (I) below or a pharmaceutically acceptable salt thereof useful for treating and/or preventing various diseases induced by hyperactivity of alpha2c-adrenoceptor (for example, Parkinson's disease, L-DOPA-induced dyskinesia, tardive dyskinesia and depression) and the like. {wherein p represents an integer of 1 to 3; R<1 >represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R<2 >represents -N(-R<4>)(-R<5>) (wherein R<4 >and R<5 >are the same or different, and each represents a hydrogen atom, substituted or unsubstituted aralkyl, or the like, or R<4 >and R<5 >form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or the like; and -Q- represents -N=C(-R<7>)- [wherein R<7 >represents -N(-R<9>)(-R<10>) (wherein R<9 >and R<10 >are the same or different, and each represents substituted or unsubstituted aralkyl, or the like, or R<9 >and R<10 >form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or the like] or the like}
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