发明名称 |
Liquid interferon-beta formulations |
摘要 |
Stable interferon-beta (I) solution of neutral or slightly acid pH (pH 5-8) is new. Liquid formulations of human (I), that retain at least 80% of in vitro biological activity after storage for 3 months at 25 degrees Centigrade, contain up to 25 MU (units)/ml of (I), are buffered to pH 5-8, preferably over 5.5, and are free of human serum albumin (HSA); are buffered to pH 6-7.2 and are free of HSA, or are buffered to pH 5-8, preferably over 5.5, and contain at least one amino acid.
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申请公布号 |
EP1426058(A2) |
申请公布日期 |
2004.06.09 |
申请号 |
EP20040005645 |
申请日期 |
1998.09.23 |
申请人 |
DR. RENTSCHLER BIOTECHNOLOGIE GMBH |
发明人 |
TSCHOEPE, MICHAEL;SIKLOSI, THOMAS;SCHROEDER, PETER;HOFER, HANS |
分类号 |
A61K9/08;A61K38/21;A61K47/18;(IPC1-7):A61K38/21;A61K47/20 |
主分类号 |
A61K9/08 |
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