REMEDIES FOR HEART DISEASES

摘要

This invention aims at providing a method of searching for substances that can selectively suppress apoptosis in cardiovascular cells. <??>This objective is attained by providing a method of screening for therapeutic and/or prophylactic agents of cardiac disease, which comprises the steps of inducing apoptosis in cultured myocardial cells and/or cultured vascular endothelial cells; treating the cells with a Cl<-> channel blocker under test; and evaluating the therapeutic and/or prophylactic effect of the blocker under test on cardiac disease by checking to see if it can suppress apoptotic cell death in the cardiovascular cells or vascular endothelial cells.