| 摘要 |
Novel pyridine-based thyroid receptor ligands are provided which have the general formula Iwherein:X is oxygen (-O-), sulfur (-S-), sulfoxide (-S(O)-), sulfonyl (-SO2-), CR8R8 or NR8;Y is -NR8, oxygen (-O-), -CH2- or sulfur (-S-);Z is a bond or substituted or unsubstituted C1-4 alkyl; andwherein the substituents are as described herein.In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.
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