| 摘要 |
The invention relates to peptidomimetic compounds with formulawherein Z=CH2 and Y=CH2, or Z=O and Y=O=O, which are novel analogs of glutathion and are inhibitors of glutathione S-transferase, in particular of GST P1-1. Such inhibition has beneficial effects in therapy against cancer. In particular compounds in which R3 is H, R4 is benzyl and R5 is phenyl are stable towards gammaGT activity and are selective for GST P1-1.
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