发明名称 |
Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion |
摘要 |
Sulfonamide derivatives, their physiologically tolerable salts and their prodrugs according to the present invention are vitronectin receptor antagonists and inhibitors of cell adhesion, as well as inhibit bone resorption by osteoclasts. These derivatives, salts and prodrugs are pharmaceutically active compounds useful in the therapy and prophylaxis of diseases which are caused at least partially by an undesired extent of bone resorption, for example of osteoporosis. Processes for the preparation of the sulfonamide derivatives according to the present invention, the use of these derivatives as pharmaceutically active ingredients, and pharmaceutical preparations comprising these derivatives also are disclosed.
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申请公布号 |
US6747148(B2) |
申请公布日期 |
2004.06.08 |
申请号 |
US20010972190 |
申请日期 |
2001.10.09 |
申请人 |
HOECHST MARION ROUSSEL DEUTSCHLAND GMBH;GENENTECH, INC. |
发明人 |
PEYMAN ANUSCHIRWAN;WILL DAVID WILLIAM;KNOLLE JOCHEN;SCHEUNEMANN KARLHEINZ;CARNIATO DENIS;GOURVEST JEAN-FRANCOIS;GADEK THOMAS R.;MCDOWELL ROBERT;BODARY SARAH CATHERINE;CUTHBERTSON ROBERT ANDREW |
分类号 |
C07D233/88;C07D239/16;C07D409/12;(IPC1-7):C07C211/119;C07D239/26 |
主分类号 |
C07D233/88 |
代理机构 |
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