1,2,4-TRIAZOLE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

PURPOSE: 1,2,4-Triazole derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same are provided, which compounds have improved fever-removing, pain-alleviating and anti-inflammatory activities and improve side-effects of conventional non-steroidal anti-inflammatory agents. CONSTITUTION: The 1,2,4-triazole derivatives represented by formula (1) or non-toxic salts thereof are provided, wherein R1 is naphthyl, indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzothiazolyl, benzotriazolyl, benzoxazolyl, quinolinyl, isoquinolinyl, or a mixture thereof substituted with one selected from halogen, hydroxy, nitro, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, cyano, amino, monoalkylamino and dialkylamino; R2 is methyl or amino; and A, B, C and D are independently carbon or nitrogen.