| 摘要 |
PROBLEM TO BE SOLVED: To obtain an anticancer agent effective for treating malignant tumors, especially, ovarian cancer. SOLUTION: This anticancer agent contains a protein which comprises a variant of a diphtheria toxin, has activity of hindering an HB (hepatitis B)-EGF (epidermal growth factor) from binding to a EGF receptor, and does not substantially have toxicity of the diphtheria toxin, or the other protein which comprises a part of the diphtheria toxin and contains at least a receptor binding domain of the diphtheria toxin, or comprises a conjugated protein, or the like, containing the other protein, and has the activity of hindering the HB-EGF from binding to the EGF receptor, and does not substantially have the toxicity of the diphtheria toxin, as an active ingredient. COPYRIGHT: (C)2004,JPO
|
