CONFORMATION-ACTIVITY RELATIONSHIP OF APOPTOSIS-INDUCING PHOSPHODIESTER OLIGONUCLEOTIDES

摘要

The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity and the efficacy of the biological activity based on the three-dimensional structure and charge characteristics of the oligonucleotides. Biological activities include, but are not limited to, cellular proliferation, induction of cell cycle arrest and apoptosis.