发明名称 |
Screening assay for antagonists of human leukocyte receptors |
摘要 |
A method of screening compounds for their ability of inhibiting ligand-induced co-stimulatory receptor internalisation pathways in immune competent human cells is described. The immune competent human cells are incubated at conditions capable of inducing co-stimulatory receptor internalisation in the presence of at least one test compound and the suppression of the ligand-induced co-stimulatory receptor internalisation is determined. There is also described a kit for use in such a method, as well as an immunoregulatory drug capable of blocking down-modulation of a ligand-induced receptor.
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申请公布号 |
US2004106160(A1) |
申请公布日期 |
2004.06.03 |
申请号 |
US20030432726 |
申请日期 |
2003.06.20 |
申请人 |
XU ZHENYI;MICHAELSSON K M ERIK;PETERSSON LEIF;SORENSEN PAUL |
发明人 |
XU ZHENYI;MICHAELSSON K M ERIK;PETERSSON LEIF;SORENSEN PAUL |
分类号 |
G01N33/48;A61K38/13;A61K45/00;A61P37/02;C12N15/09;C12Q1/02;C12R1/91;G01N33/15;G01N33/50;G01N33/566;G01N33/567;G01N33/58;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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