发明名称 |
DROSOPHILA G PROTEIN COUPLED RECEPTORS, NUCLEIC ACIDS, AND METHODS RELATED TO THE SAME |
摘要 |
The present invention provides Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention also provides methods for the identification of homologues in other species and of DmGPCR agonists/antagonists useful as potential insecticides. The invention further provides methods for binding a DmGPCR, methods for identifying modulators of DmGPCR expression and activity, methods for controlling a population of insects with a DmGPCR antibody, a DmGPCR antisense polynucleotide, a DmGPCR binding partner or modulator, and methods of preventing or treating a disease or condition associated with an ectoparasite. Specifically, this invention discloses the matching of the orphan Drosophila short neuropeptide F receptor with its cognate peptide ligands. |
申请公布号 |
WO2004013306(A3) |
申请公布日期 |
2004.06.03 |
申请号 |
WO2003US24488 |
申请日期 |
2003.08.06 |
申请人 |
PHARMACIA & UPJOHN COMPANY;LOWERY, DAVID, E.;SMITH, VALDIN, G.;KUBIAK, TERESA, M.;LARSEN, MARTHA, J. |
发明人 |
LOWERY, DAVID, E.;SMITH, VALDIN, G.;KUBIAK, TERESA, M.;LARSEN, MARTHA, J. |
分类号 |
G01N33/50;A01N63/00;A61K38/00;A61K39/395;A61K45/00;A61P33/14;C07K14/435;C07K14/705;C12N15/00;C12N15/09;C12N15/12;G01N33/15 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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