CANCER MODELS

摘要

The invention provides chimeric non-human animals, methods for making and using chimeric non-human animals, isolated stem cells, and methods for identifying agents that reduces cancer in a non-human animal. For example, the invention relates to using stem cells to make chimeric non-human animals having cancer or the ability to develop cancer. Such animals can be used to evaluate tumorigenesis, tumor maintenance, and tumor regression in vivo. In addition, the chimeric non-human animals provided herein can be used to identify agents that reduce or prevent tumor formation or growth in vivo.