| 摘要 |
PROBLEM TO BE SOLVED: To provide a sustained release pharmaceutical preparation for treating diseases associated with neovascularization, especially a sustained release pharmaceutical preparation for suppressing infiltration and metastasis of cancer. SOLUTION: This sustained release pharmaceutical preparation comprises NK (natural killer) 4 DNA and a biodegradable polymeric hydrogel. A composition for inhibiting neovascularization is composed of the sustained release pharmaceutical preparation comprising the NK4 DNA and biodegradable polymeric hydrogel. The composition is useful as a therapeutic agent for cancer by suppressing the infiltration and metastasis of the cancer and useful as a therapeutic agent and a prophylactic agent for ophthalmologic diseases such as age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity, and diseases associated with neovascularization such as anginoma, rheumatoid arthritis, psoriasis and edematous scleredema. COPYRIGHT: (C)2004,JPO
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