发明名称 |
RNAI-BASED SENSORS, CAGED INTERFERING RNAS, AND METHODS OF USE THEREOF |
摘要 |
Methods of using labeled interfering RNAs to detect and/or quantitate target mRNAs in cells are provided. Related compositions, systems, and kits are also provided. Caged interfering RNAs (e.g., photoactivatable interfering RNAs), methods of using such caged RNAs, and related systems and kits are also provided. Methods and compositions for introducing interfering RNAs into cells, using RNAs covalently associated with protein transduction domains and/or lipids, are provided. Also provided are methods and compositions for selectively attenuating expression of a target mRNA by controlling expression of an interfering RNA. |
申请公布号 |
WO2004045547(A2) |
申请公布日期 |
2004.06.03 |
申请号 |
WO2003US36889 |
申请日期 |
2003.11.17 |
申请人 |
GENOSPECTRA, INC.;NGUYEN, QUAN;MCMASTER, GARY |
发明人 |
NGUYEN, QUAN;MCMASTER, GARY |
分类号 |
A61K48/00;C07H21/02;C12N15/85;C12Q1/00;C12Q1/37;C12Q1/48;C12Q1/68;G01N33/542;G01N33/573 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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