| 摘要 |
The present invention provides a therapeutic agent for bladder hypersensitivity comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein R<1 >represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy or halogen; X<1>-X<2>-X<3 >represents CR<5>=CR<6>-CR<7>=CR<8>, N(O)m=CR<6>-CR<7>=CR<8>, CR<5>=CR<6>-N(O)m=CR<8>, CR<5>=CR<6>-CR<7>=N(O)m, CR<5>=CR<6>-O, CR<5>=CR<6>-S, O-CR<7>=CR<8>, S-CR<7>=CR<8 >or O-CR<7>=N; Y represents -CH2S-, -CH2SO-, -CH2SO2-, -CH2O-, -CH=CH-, -(CH2)p-, -SCH2-, -SOCH2-, -SO2CH2- or -OCH2-; and R<2 >represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkoxy, amino, mono(substituted or unsubstituted lower alkyl)-substituted amino, di(substituted or unsubstituted lower alkyl)-substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkylamino, substituted or unsubstituted arylamino or a substituted or unsubstituted heteroalicyclic group] or a pharmaceutically acceptable salt thereof.
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