发明名称 |
Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
摘要 |
The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence, asymmetric hydrogenation of a lactam-enamide was performed to produce an intermediate that can ultimately be converted to a series of pharmaceutical compounds. The invention also contemplates the in situ synthesis of an intermediate of the multi-step synthesis, which provides economic advantages to the overall synthesis of the lactam compounds.
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申请公布号 |
US2004106593(A1) |
申请公布日期 |
2004.06.03 |
申请号 |
US20030721714 |
申请日期 |
2003.11.25 |
申请人 |
BOAZ NEIL WARREN;DEBENHAM SHERYL DAVIS |
发明人 |
BOAZ NEIL WARREN;DEBENHAM SHERYL DAVIS |
分类号 |
B01J31/24;C07B61/00;C07C231/18;C07C233/47;C07C233/83;C07C233/84;C07C253/30;C07C255/60;C07C269/06;C07C271/22;C07D203/04;C07D205/08;C07D207/26;C07D207/27;C07D211/76;C07D223/10;C07D225/02;C07F9/553;C07F9/564;C07F9/568;C07F9/572;C07F9/576;C07F9/59;(IPC1-7):A61K31/397;A61K31/55;A61K31/445;A61K31/401 |
主分类号 |
B01J31/24 |
代理机构 |
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地址 |
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