A METHOD FOR THE CRYSTALLIZATION OF HUMAN SERUM ALBUMIN
摘要
The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process include providing specific reaction conditions and precipitating reagents to maximize albumin crystallization. Solubility diagrams are utilized as the basis for process control of the invented method. The current invention specifically controls phosphate concentration, pH and temperature to precisely guide crystallization kinetics and crystal yield.
申请公布号
WO2004046311(A2)
申请公布日期
2004.06.03
申请号
WO2003US34205
申请日期
2003.10.28
申请人
GTC BIOTHERAPEUTICS, INC.;VISURI, KALEVI;UOTILA, SINIKKA;FULTON, SCOTT, P.;COUTO, DANIEL, E.
发明人
VISURI, KALEVI;UOTILA, SINIKKA;FULTON, SCOTT, P.;COUTO, DANIEL, E.