METHODS AND COMPOSITIONS FOR THERAPIES USING GENES ENCODING SECRETED PROTEINS SUCH AS INTERFERON-beta

摘要

PROBLEM TO BE SOLVED: To eliminate problems (stabilization of a protein, reduction of adverse effect) accompanied with the delivery of a secreted protein such as an interferon protein as a therapeutic agent.

SOLUTION: Methods and pharmaceutical compositions for modifying cells of a mammalian recipient with DNA encoding the secreted proteins such as the human interferon in situ are provided. The methods include forming a secreted protein expression system in vivo or ex vivo and administering the expression system to the mammalian recipient. The expression system and methods are useful for the localized and systemic delivery of interferons in situ.

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