发明名称 |
CHEMOSENSITIZATION BY A NON-APOPTOGENIC HEAT SHOCK PROTEIN 70-BINDING APOPTOSIS INDUCING FACTOR MUTANT ADD70 |
摘要 |
The present invention is aimed at a non-toxic apoptosis-inducing factor derivative having chemosensitizing properties, referred as ADD70, allelic variants, isoforms and analogs thereof, wherein the ADD70 polypeptide comprises the sequence involved in the binding with HSP70 but not the sequence implicated in the DNA damaging activity of the apoptosis-inducing factor (AIF). |
申请公布号 |
WO2004046180(A2) |
申请公布日期 |
2004.06.03 |
申请号 |
WO2003IB05858 |
申请日期 |
2003.11.14 |
申请人 |
INSTITUT GUSTAVE-ROUSSY;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);KROEMER, GUIDO;GARRIDO, CARMEN |
发明人 |
KROEMER, GUIDO;GARRIDO, CARMEN |
分类号 |
A61K38/00;C07K14/47;C12N15/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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