| 摘要 |
PROBLEM TO BE SOLVED: To provide a method of manufacturing a tissue factor-based prothrombin time (PT) reagent that reproducibly yields a suitably sensitive tissue factor-based PT reagent. SOLUTION: The method of manufacturing a tissue factor-based prothrombin time (PT) reagent includes a step of combining in which predetermined quantities of tissue factor (TF), phospholipid, and detergent-containing buffer are combined to create a TF/phospholipid mixture and a step of removing in which the detergent is removed from the TF/phospholipid mixture to produce an essentially detergent-free TF/phospholipid mixture by which the tissue factor-based PT reagent is produced. The predetermined quantities of TF is based upon its measured TF activity. COPYRIGHT: (C)2004,JPO
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