发明名称 |
SUBSTITUTED INDOLEPYRIDINIUM AS ANTI-INFECTIVE COMPOUNDS |
摘要 |
The present invention concerns the compounds of formula (1) (R3)n P(I) N O R1 R2 their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(=O), C(=O)OH, C1-4-alkyloxyC(=O), C1-4alkylC(='O), mono- or di(C1-4alkyl)aminoC(=O), arylaminoC(=O), N-(aryl)-N-(C1-4alkyl)aminoC(=O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10allkenyl, C3-7cycloalkyl, wherein said C1-10alkyl,C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy,C1-4alkyloxy, hydroxyC(=O), aminoC(=O), C1-4alkyloxyC(=O), mono- or di(C1-4-alkyl)aminoC(=O), C1-4alkylC(=O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I). |
申请公布号 |
WO2004046143(A1) |
申请公布日期 |
2004.06.03 |
申请号 |
WO2003EP50837 |
申请日期 |
2003.11.14 |
申请人 |
TIBOTEC PHARMACEUTICALS LTD.;KESTELEYN, BART, RUDOLF, ROMANIE;VAN DE VREKEN, WIM;KINDERMANS, NATALIE, MARIA, FRANCISCA;CANARD, MAXIME, FRANCIS, JEAN-MARIE, GHISLAIN;HERTOGS, KURT;BETTENS, EVA;DE VROEY, VERONIQUE, CORINE, PAUL;JOCHMANS, DIRK, EDWARD, DESIRE |
发明人 |
KESTELEYN, BART, RUDOLF, ROMANIE;VAN DE VREKEN, WIM;KINDERMANS, NATALIE, MARIA, FRANCISCA;CANARD, MAXIME, FRANCIS, JEAN-MARIE, GHISLAIN;HERTOGS, KURT;BETTENS, EVA;DE VROEY, VERONIQUE, CORINE, PAUL;JOCHMANS, DIRK, EDWARD, DESIRE |
分类号 |
A61K31/437;A61P31/12;C07D471/00;C07D471/04 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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地址 |
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